Multi-Year Study Conducted with Amgen Identified Mutations in KRAS / NRAS (RAS) Exons in Tumors from Metastatic Colorectal Cancer Patients using Sanger Sequencing

OMAHA, Neb. (October 13, 2015) — Transgenomic, Inc. (NASDAQ: TBIO) today announced that it presented a poster last week at CAP ’15, the annual meeting of the College of American Pathologists. The poster, which was co-authored by researchers from Transgenomic and Amgen, reported on the results of analysis of tumor tissue from two randomized clinical trials using Sanger sequencing. The analysis concluded that the use of validated assays, relevant controls, and assay-specific tissue requirements resulted in highly reproducible Sanger sequencing data from the FFPE clinical specimens.1

Transgenomic provided pharmacogenomic services that included identification of mutations in KRAS exons 3 & 4 / NRAS exons 2-4 (collectively, RAS) in more than 2000 metastatic colorectal cancer patients. The focus of this analysis was to determine whether accuracy of detection of RAS mutations is affected by analytical methods and sample preparation.

Katherine Richardson, PhD, Transgenomic Vice President of Research & Development, noted, “This multi-year project conducted with our colleagues at Amgen is a good example of how Transgenomic can work with our biopharmaceutical clients to generate data relevant to actionable mutations. In this project, we obtained reproducible data from patient FFPE tissue samples using Sanger sequencing. This analysis generated data that contributes to the advancement of personalized medicine.”

1 Extended RAS Mutation Testing in Metastatic colorectal cancer. Catherine Lofton-Day, Scott D. Patterson, Benjamin L. Legendre Jr., Katherine Richardson, CAP ’15, Nashville, TN, October 5, 2015.

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About Transgenomic
Transgenomic, Inc. is a global biotechnology company advancing personalized medicine in cardiology, oncology, and inherited diseases through advanced diagnostic technologies, such as its revolutionary ICE COLD-PCR™ and its unique genetic tests provided through its Patient Testing business. The company also provides specialized clinical and research services to biopharmaceutical companies developing targeted therapies and sells equipment, reagents and other consumables for applications in molecular testing and cytogenetics. Transgenomic’s diagnostic technologies are designed to improve medical diagnoses and patient outcomes.

Forward-Looking Statements
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Barbara Lindheim

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